The Endocannabinoid System and CBDs

The Endocannabinoid system: A Multi-Faceted Target

  • Despite being used as a treatment and healing remedy for 10,000 years, only recently has it become “known” that endocannabinoids have roles in the pathology of many disorders and they also serve as a “protective role” in many medical conditions.


Several diseases like emesis, pain, inflammation, multiple sclerosis, anorexia, epilepsy, glaucoma, schizophrenia, cardiovascular disorders, cancer, obesity, metabolic syndrome related diseases, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease and Tourette’s syndrome could possibly be treated by drugs modulating endocannabinoid system.

Terpenoids & CBDs as important componets to Medicinal Cannabis

“Due to its astonishing efficacy, nowadays cannabis is prescribed by physicians for the treatment of neurological, psychiatric, immunological, cardiovascular, gastrointestinal, and oncological conditions. The active principles inside plants have been exploited by humans for centuries, with Cannabis sativa being one of the oldest ever used for medicinal purposes. Surprisingly, contrary to whole plant extracts, medicinal products containing exclusively THC have been found to lack efficacy and lead to unbearable side effects. These results arise from the fact that these products lack other important co-factors typically found in the Phyto-complex, such as terpenoids and other cannabinoids that contribute to the synergistic effects seen with whole plant extracts.” 

Does it get you high?

Grotenhermen, F., Russo, E., & Zuardi, A. W. (2017). Even High Doses of Oral Cannabidol Do Not Cause THC-Like Effects in Humans: Comment on Merrick et al. Cannabis and Cannabinoid Research 2016;1(1):102–112; DOI: 10.1089/can.2015.0004. Cannabis and Cannabinoid Research, 2(1), 1–4.

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